Understanding and Resetting Radiation Sensitivity in Rectal Cancer
نویسندگان
چکیده
منابع مشابه
Understanding and Resetting Radiation Sensitivity in Rectal Cancer.
OBJECTIVE The aim of the study was to explore specific microRNAs (miRs) in rectal cancer that would predict response to radiation and identify target pathways that may be exploited for neoadjuvant therapies. SUMMARY BACKGROUND DATA Chemoradiotherapy (CRT) response is a predictor of survival in rectal cancer. Studies have demonstrated changes in RNA expression correlate with chemoradiation sen...
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Introduction: Radiation therapy is one of the main treatments for rectal cancer. In three-dimensional conformal radiotherapy, exposure of healthy tissue around the tumor is unavoidable. The small intestine is the most important organ at risk of rectal cancer radiotherapy. Intestinal complications are a major factor limiting the dose radiotherapy for rectal cancer. The most com...
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Rectal cancer is the second most common cancer in large intestine. The prevalence and the number of young patients diagnosed with rectal cancer have made it as one of the major health problems in the world. With regard to the improved access to and use of modern screening tools, a number of new cases are diagnosed each year. Considering the location of the rectum and its adjacent organs, ma...
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Over the past 25 years, significant advances have been made in the management of patients with rectal cancer. Phase III studies have shown the efficacy of postoperative radiation therapy and chemotherapy in improving local control and survival of patients with resected stage II and III disease. Data from the randomized German CAO/ARO/AIO-94 trial of preoperative versus postoperative chemoradiat...
متن کاملRadiation therapy for rectal cancer: current status and future directions.
BACKGROUND Treatment for rectal cancer has evolved over the past 70 years from surgery alone to the selective use of trimodality therapy for high-risk patients. Radiotherapy (RT) has improved the potential for tumor downstaging, thus enhancing sphincter preservation and local control. METHODS This article reviews the evolution of strategies that incorporate pelvic RT, intraoperative RT, and h...
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ژورنال
عنوان ژورنال: Annals of Surgery
سال: 2017
ISSN: 0003-4932
DOI: 10.1097/sla.0000000000002409